Scientist/Senior Scientist - Next Generation Sequencing
RhoDx, Inc. is looking for an experienced Scientist/Senior Scientist with expertise in next generation sequencing (NGS), sample preparation methods, and bioinformatics-driven approaches to data analysis. This is an opportunity to work side by side with prominent researchers and entrepreneurs in developing the company’s proprietary technologies that will power the next generation of tools for cancer screening and characterization.
RhoDx is a development stage biotech company poised to commercialize technologies that improve upon existing methods to detect the genetic and epigenetic alterations that underlie cancer and other diseases. Our mission is to leverage these technologies to improve liquid biopsy and enable more scalable, sensitive, and descriptive detection of cancer. We believe better methods for screening and monitoring cancer will have the biggest impact on patient outcomes this decade. We seek curious and motivated scientists to join us.
This position at our St Louis site will focus on basic and clinical development of our three core technologies – NexGenAbler™, a cell-free DNA library prep method; PointSuppressor™, a powerful new approach for rare allele detection; and MethylMarker™, a DNA methylation detection method compatible with mutation detection. The candidate should have strong hands-on experience in NGS with a deep understanding of sample prep workflows. The successful candidate must have a strong background in NGS data analysis with previous experience in bioinformatics a plus. This position will involve working directly with senior management to overcome the technical challenges of assay development. Good interpersonal and presentation skills are essential with the opportunity to communicate findings to external stakeholders.
Duties and Responsibilities
- Design, execute, and analyze experiments to support optimization of NGS assays incorporating RhoDx core technologies.
- Lead experiments to qualify, validate, and document assays for performance in relevant clinical samples.
- Contribute to development of the RhoDx data analysis pipeline.
- Assist in writing protocols and other technical materials to support assay development.
- Assist in developing scientific strategy based on literature and peer interaction at relevant conferences.
- Independently communicate findings both internally and externally in written and oral forums.
- Education/experience: PhD in Molecular Biology, Bioengineering, Bioinformatics, or a closely related field. MS with equivalent experience will be equally considered.
- Professional experience: 2 or more years post graduate laboratory experience with extensive hands-on experience in NGS.
- Experience in related methods such as nucleic acid purification, electrophoresis, and general molecular biology techniques.
- Demonstrated knowledge of bioinformatics methods.
- Familiarity in bioinformatics application programming, especially python, a plus.
- Hands-on experience with multiplex PCR a plus
- Demonstrated strong project management skills with ability to multitask and function in a dynamic, entrepreneurial environment.
- Excellent written and verbal communication skills including ability to contribute to publications, grant submissions, and oral presentations. Demonstrated high impact publication record a plus.